Qsymia is an appetite suppressant with side effects and it's not clear why it works. It tends to help you feel full. It works for me. But what it helps you do is CICO. For me in particular, it lets me eat one "normal" meal a day and the other meals light. I feel full in the evening so I don't feel hungry.Phentermine Results after 3 Months. First of all, let us clarify if you take Phentermine HCL without any special diet or exercise plan, it is possible to lose around 8 pounds within the 3 months ...weight loss. impaired taste (changes in how things taste) trouble with memory. More common side effects in people taking Topamax for epilepsy include: tingling in the legs and arms. loss of ...Side effects Interactions FAQ What is Qsymia? Qsymia contains a combination of phentermine and topiramate in an extended-release capsule. Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is typically used as a seizure medication, also called an anticonvulsant.What Is Wegovy? Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e ...Oct 26, 2022 · Common Qsymia side effects may include: joint pain, ankle sprain; flu-like symptoms; dizziness; constipation; numbness or tingly feeling; sleep problems (insomnia); dry mouth, changes in your sense of taste; or. mood changes, feelings of low self-worth, loss of interest in things you once enjoyed, ... In clinical studies, patients lost the most weight after taking Contrave for 36 weeks and maintained weight loss through 56 weeks. In terms of phentermine weight loss, studies were only done for a short period of time. Once you stop phentermine, your appetite will return to normal. As a result, weight gain may occur.What Is Wegovy? Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e ...Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...Objective: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. Methods: Using electronic health record data, 13,972 adults were identified with a first phentermine fill in 2010 to 2015, creating exposure categories according to a patient's duration of use (referent: ≤ 3 months). Phentermine acts much like a stimulant and has many of the same side effects: increased heart palpitations. increased blood pressure. dizziness. Phentermine is known for being one part of Fen-Phen ...Introduction. The worldwide prevalence of overweight and obesity, defined as having a body mass index (BMI) between 25.0–29.9 kg/m 2 and ≥30.0 kg/m 2, 1 has almost tripled since the 1970s, with nearly 40% of adults being overweight and 13% obese, and these numbers have been steadily increasing. 2 Patients with obesity are at an increased risk of developing comorbidities such as ...After stopping phentermine, some people experience feelings of weariness and fatigue due to the sudden lack of chemical stimulation. If you are tired after stopping phentermine, take care to: Get enough sleep. Fuel your body with healthy foods: avoid high-fat, high-carb, and high-sugar goods that may worsen fatigue. Stay lightly active.COMMON SIDE EFFECTS OF QSYMIA IN CHILDREN 12 YEARS OLD AND OLDER INCLUDE: Depression, dizziness, joint pain, fever, flu, and ankle sprain. POSSIBLE SIDE EFFECTS OF QSYMIA INCLUDE: Mood changes and trouble sleeping. Qsymia may cause depression or mood problems, and trouble sleeping. Tell your healthcare provider if symptoms occur.Places you in a long-term behavioral changing plan; The Cons. Serious side-effects; Some people didn’t notice that many benefits; The results they claim are underwhelming; Qsymia Conclusion. Qsymia is an example of a prescription drug for weight loss that might do more harm than good.Apr 30, 2014 · This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment. Jun 28, 2023 · Extreme happiness or sadness. Symptoms of dangerously high blood pressure, such as severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, or seizures. These symptoms can indicate a serious phentermine side effect. Common Side Effects of Weight Loss Drugs. Increased blood pressure and heart rate, insomnia, nervousness, restlessness, dependence, abuse or withdrawal may occur with long-term use. When given as a single agent, phentermine is not implicated in valvular heart disease; avoid use at bedtime.These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about ...Feb 14, 2023 · Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Side effects include: Oily spotting ... Qsymia (phentermine and topiramate) is a weight loss medication used to help people who are overweight or obese, along with diet and exercise, to lose weight and keep the weight off. Common side effects of Qsymia include sensations of pricking, burning, tingling, or numbness of the skin; dizziness, blurred vision, fatigue, indigestion, urinary tract infections (UTIs), headache, nausea, back ...or short-term obesity treatment in conjunction with lifestyle modifications, but is commonly used chronically. Topiramate, approved for treating epilepsy and preventing migraines, also induces weight loss. A single-dose combination of low-dose phentermine and topiramate extended-release was recently approved by the United States Food and Drug Administration as an adjunct to lifestyle ...Phentermine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phentermine belongs to the group of medicines known as appetite suppressants. This medicine is available only with your doctor's prescription.Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use.Using nonexposed periods in former users as a comparison achieves partial balance for obesity status. Second, because the signal of potential concern with Qsymia is increased heart rate—an effect that does not persist after the drug is withdrawn—the potential for carryover effects beyond current use was considered remote. Key variablesIn fact, this sort of weight loss is referred to as yo-yo dieting (yes, even if it comes secondary to the use of prescription medication) and can cause some serious long-term problems. #2. Using Phentermine Daily Can and Dose Cause Metabolic Damage. Perhaps the single biggest reason to avoid using Phentermine is that it can cause something ...What Are Side Effects of Qsymia? Side effects of Qsymia can include: mood changes such as depression, trouble sleeping (insomnia), confusion, dizziness, anxiety, tiredness, irritability, constipation, numbness or tingly feeling, altered sense of taste, dry mouth, unpleasant taste in your mouth, headache, upper respiratory tract infection,Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...Side effects Interactions FAQ What is Qsymia? Qsymia contains a combination of phentermine and topiramate in an extended-release capsule. Phentermine is an appetite suppressant similar to an amphetamine. Topiramate is typically used as a seizure medication, also called an anticonvulsant.Feb 14, 2023 · Summary. Commonly reported side effects of orlistat include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Nov 2, 2022 · Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use. Jun 28, 2023 · Extreme happiness or sadness. Symptoms of dangerously high blood pressure, such as severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, or seizures. These symptoms can indicate a serious phentermine side effect. Aug 4, 2022 · Other side effects. Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Aug 3, 2023 · What Is Wegovy? Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adult patients with an initial body mass index (BMI) of 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e ... Places you in a long-term behavioral changing plan; The Cons. Serious side-effects; Some people didn’t notice that many benefits; The results they claim are underwhelming; Qsymia Conclusion. Qsymia is an example of a prescription drug for weight loss that might do more harm than good.From research studies, an outline of the common and rare side effects associated with Qsymia is as follows: Common side effects (reported in more than 1% of patients): Paresthesia (tingling, numbness) of the extremities (15-38%) Dizziness (11-28%) Dysgeusia (abnormal taste sensation) (6-19%) Insomnia (7-17%) Constipation (6-16%)At 6 months, a year, and 2 years after starting phentermine, weight loss was clinically significantly greater among people who used the medication longer-term (more than a year) or medium-term (more than112 days but less than a year) than in people who used it for only 3 months.PHEN is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. It has been available in the US since 1959 for short-term (generally regarded as 12 weeks) treatment of obesity in dose range of 15 mg/day to 37.5 mg/day.Sep 30, 2022 · Along with its needed effects, liraglutide (the active ingredient contained in Saxenda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking liraglutide: More common. Bladder pain Feb 1, 2023 · Phentermine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phentermine belongs to the group of medicines known as appetite suppressants. This medicine is available only with your doctor's prescription. After stopping phentermine, some people experience feelings of weariness and fatigue due to the sudden lack of chemical stimulation. If you are tired after stopping phentermine, take care to: Get enough sleep. Fuel your body with healthy foods: avoid high-fat, high-carb, and high-sugar goods that may worsen fatigue. Stay lightly active.Qsymia (phentermine and topiramate) is a weight loss medication used to help people who are overweight or obese, along with diet and exercise, to lose weight and keep the weight off. Common side effects of Qsymia include sensations of pricking, burning, tingling, or numbness of the skin; dizziness, blurred vision, fatigue, indigestion, urinary tract infections (UTIs), headache, nausea, back ... This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment.Apr 8, 2013 · PHEN is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. It has been available in the US since 1959 for short-term (generally regarded as 12 weeks) treatment of obesity in dose range of 15 mg/day to 37.5 mg/day. Uses. This medication is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used by certain overweight people, such as those who ...The Saxenda Savings Card allows you to pay as little as a $25 copay or save up to $200 per Saxenda prescription. The Savings Card program allows for up to 12 benefits annually. There are eligibility requirements, and other restrictions apply. According to GoodRX, out-of-pocket prices range from $1332.59 to $1432.91.Qsymia has an average rating of 7.7 out of 10 from a total of 564 reviews on Drugs.com. 71% of reviewers reported a positive experience, while 15% reported a negative experience. Condition.Qsymia is significantly more expensive than phentermine-only pills, costing about $200 per month without insurance. The combined pill has a long list of potential side effects, including severe birth defects if taken while pregnant. This is a newer medication (FDA approval in 2012), so long-term side effects remain relatively unknown. Summary.Using nonexposed periods in former users as a comparison achieves partial balance for obesity status. Second, because the signal of potential concern with Qsymia is increased heart rate—an effect that does not persist after the drug is withdrawn—the potential for carryover effects beyond current use was considered remote. Key variablesStudies show that on average, people taking Topamax lose around 11 lbs. Higher doses and longer duration of use generally result in more weight loss. The most common side effects associated with Topamax for weight loss are abnormal skin sensations (like burning, tingling, numbness), altered sense of taste, and slowed thinking and movements.The latest weight loss drugs work in a new way to help you shed pounds with minimal side effects. Learn how they do it and why you take them long term. ... (Qsymia®): This medication also ...Apr 11, 2017 · Serious side effects vary by drug but can include depression, heart palpitations, fast or irregular heartbeat, increased blood pressure, dizziness, tremors, chest pain, and difficulty breathing ... This review showed that combining low doses of phentermine and topiramate for the treatment of obesity minimized side effects while maintained weight loss efficacy. The side effects were paraesthesia, taste changes and dry mouth. Weight loss induced by the combination was associated with improved BP through one and two years of treatment.Jun 28, 2023 · Symptoms of severe phentermine side effects include ( 3 , 4 ): Chest pain. Pounding or irregular heartbeat, or fluttering in your chest. Lightheadedness or faintness. Shortness of breath, even with only mild exertion. Swelling in your legs, ankles, or feet (edema) Slurred speech or weakness on one side of your body. Feb 14, 2023 · Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. Other side effects include: fecal incontinence. Continue reading for a comprehensive list of adverse effects. Applies to orlistat: oral capsules. Side effects include: Oily spotting ... During the last few decades, some anti-obesity drugs were used to treat morbid obesity; however, many of them were removed from the market owing to long-term side effects, particularly cardiovascular issues . Since then, anti-obesity drug development process focusses on both weight loss efficacy and cardiovascular safety.Qsymia Dosage and Administration. Take orally once daily in morning. Avoid administration in evening to prevent insomnia ( 2.3 ). Recommended starting dosage is 3.75 mg/23 mg (phentermine mg/topiramate mg) daily for 14 days; then increase to 7.5 mg/46 mg daily ( 2.3 ). Phentermine is used as part of a short-term plan, along with a low calorie diet, for weight reduction. It is used in obese patients who have not been able to lose weight with diet and exercise alone. Phentermine belongs to the group of medicines known as appetite suppressants. This medicine is available only with your doctor's prescription.In clinical studies, phentermine-topiramate reduced body weight by 8.6% to 9.4% more than placebo using a conservative ITT analysis.108. Phentermine-topiramate carries risks of several serious side effects. Notably, topiramate is a recognized teratogen, at least at the higher doses used for the treatment of epilepsy.Approved for long-term use? Yes. Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone. Side effects: The most common side effects are tingling hands ...What Are Side Effects of Qsymia? Side effects of Qsymia can include: mood changes such as depression, trouble sleeping (insomnia), confusion, dizziness, anxiety, tiredness, irritability, constipation, numbness or tingly feeling, altered sense of taste, dry mouth, unpleasant taste in your mouth, headache, upper respiratory tract infection,ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ ᅠ Select Download Format Qsymia Long Term Side Effects Download Qsymia Long Term Side Effects PDF Download Qsymia Long Term Side Effects DOC ᅠ Bottle tightly closed when topiramate can think and pregnancy, food cravings to ensure that the sponsor. Phentermine acts much like a stimulant and has many of the same side effects: increased heart palpitations. increased blood pressure. dizziness. Phentermine is known for being one part of Fen-Phen ...Phentermine (Adipex-P, Lomaira) is a prescription medicine used to lessen appetite. It can help weight loss by making you less hungry. Or it can help you feel full longer. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The combined drug is approved for long-term use.Phentermine-Topiramate Capsule, Extended Release Multiphase 24 Hr (Capsule, ER Hr) - Uses, Side Effects, and More Common Brand(S): Qsymia Generic Name(S): phentermine-topiramate Qsymia is an appetite suppressant with side effects and it's not clear why it works. It tends to help you feel full. It works for me. But what it helps you do is CICO. For me in particular, it lets me eat one "normal" meal a day and the other meals light. I feel full in the evening so I don't feel hungry.The most common side effects are tingling in the hands and feet, dizziness, change in taste, trouble sleeping, constipation and dry mouth. Qsymia can also increase your resting heart rate, affect ...Phentermine and Qsymia are both medications used for weight loss. Phentermine is only approved for short-term usage, while Qsymia is approved for long-term use. Topiramate is a medication used to treat seizures and prevent migraines. It also happens to have a noticeable weight loss effect, although it’s not approved in Canada solely for ...In fact, this sort of weight loss is referred to as yo-yo dieting (yes, even if it comes secondary to the use of prescription medication) and can cause some serious long-term problems. #2. Using Phentermine Daily Can and Dose Cause Metabolic Damage. Perhaps the single biggest reason to avoid using Phentermine is that it can cause something ...PHEN is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. It has been available in the US since 1959 for short-term (generally regarded as 12 weeks) treatment of obesity in dose range of 15 mg/day to 37.5 mg/day.1. Nausea and vomiting. Nausea is the most common semaglutide side effect. Up to 20% of people taking it for Type 2 diabetes reported nausea in clinical trials. Nausea is even more common if you’re taking the higher-dose version for weight loss. Vomiting tends to be less common than nausea.Jan 28, 2023 · Saxenda Side Effects: Long-term use of Saxenda can lead to dangerous effects, such as suicidal thoughts, impaired kidney function, pancreatitis, gallbladder disease, and increased heart rate. Short-Term Diet Pills Side Effects: Due to amphetamine-type effects, medications approved for short-term use can cause elevated heart rate and blood ... The most common side effects are tingling in the hands and feet, dizziness, change in taste, trouble sleeping, constipation and dry mouth. Qsymia can also increase your resting heart rate, affect ...trouble sleeping (insomnia) new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking (mania) other unusual changes in behavior or mood Serious eye problems which include: The SELECT trial is the long-term cardiovascular outcomes trial for Wegovy that aims to assess its effects on heart disease and stroke in patients with overweight and obesity; it is currently ongoing and expected to be completed in September 2023. Anti-obesity medication management: An evolving landscapeDuring the last few decades, some anti-obesity drugs were used to treat morbid obesity; however, many of them were removed from the market owing to long-term side effects, particularly cardiovascular issues . Since then, anti-obesity drug development process focusses on both weight loss efficacy and cardiovascular safety.Jun 17, 2022 · The options have short-term side effects and long-term risks. However, when other weight loss medications and diets have not produced adequate results, doctors may consider surgery. Jun 17, 2022 · The options have short-term side effects and long-term risks. However, when other weight loss medications and diets have not produced adequate results, doctors may consider surgery. Indeed, in the wake of the fen-phen problems, the FDA rejected all drug company efforts to win approval for new weight-loss drugs between 1999 and 2012. Since then, it has approved four drugs for ...Aug 17, 2019 · 1. In 2012, a new medication called Qsymia (with both Adipex and Topamax components) became available for weight loss. It was the first FDA approved weight loss drug in its class. The weight loss pill is a combination of 2 existing drugs: phentermine and topiramate. This combination has been shown to be a good tool for weight loss in addition ... Mar 29, 2022 · Tardive dyskinesia is a movement disorder that is a side effect of medications, especially first-generation antipsychotics. Less common causes are second-generation antipsychotics, antidepressants, mood stabilizers, antiepileptic drugs, movement disorder medications, antiemetics, and decongestants. Two medications have been approved to treat ... Nov 15, 2022 · diarrhea. dry mouth and tongue. bad taste in your mouth. constipation*. headaches*. mild allergic reaction *†. * To learn more about this side effect, see the “Side effects explained ...
Aug 4, 2022 · Other side effects. Some side effects of phentermine / topiramate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. . Lifeselector.com
It does not making you lose than reaching the idea, it is a compound that can be able to lose weight. It also leads to by increasing their absorption of physical activity and improvement Qsymia Long Term Side EffectsJan 12, 2023 · Qsymia works by reducing your appetite. In initial studies, Qsymia helped about 70% of adults lose at least 5% of their body weight after 1 year. Close to 50% of participants lost at least 10% of their body weight. When compared to Contrave, researchers found that Qsymia is usually the more effective option. 3. The table below lists prescription drugs approved by the FDA for weight loss. The FDA has approved five of these drugs—orlistat (Xenical, Alli), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), liraglutide (Saxenda), and semaglutide (Wegovy)—for long-term use.Jun 4, 2020 · This combination consists of fixed lower doses of phentermine and topiramate (3.75/23, 7/46, 11.25/69 and 15/92 mg) and is available in capsules under the brand name Qsymia. Common side effects of phentermine include nervousness, excitability, insomnia, headache, dry mouth, sweating, tachycardia, palpitations, nausea, constipation, and thirst. Sep 30, 2022 · Along with its needed effects, liraglutide (the active ingredient contained in Saxenda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking liraglutide: More common. Bladder pain 7. Wegovy (semaglutide) Wegovy is the newest FDA-approved weight-loss medication and works much the same way as Saxenda, by mimicking the action of the hormone GLP-1 to suppress hunger. Wegovy is a once-a-week injectable. Dosage is increased over the course of several weeks-to-months, until a 2.4 mg dose is achieved.Approved for long-term use? Yes. Qsymia has much lower amounts of phentermine and topiramate than when these drugs are given alone. Side effects: The most common side effects are tingling hands ...Jun 28, 2023 · After stopping phentermine, some people experience feelings of weariness and fatigue due to the sudden lack of chemical stimulation. If you are tired after stopping phentermine, take care to: Get enough sleep. Fuel your body with healthy foods: avoid high-fat, high-carb, and high-sugar goods that may worsen fatigue. Stay lightly active. Tardive dyskinesia is a movement disorder that is a side effect of medications, especially first-generation antipsychotics. Less common causes are second-generation antipsychotics, antidepressants, mood stabilizers, antiepileptic drugs, movement disorder medications, antiemetics, and decongestants. Two medications have been approved to treat ...Long-term users may also experience unwanted long-term side effects resulting from changes to physiology and neurobiology that accumulate over an extended period of time. Individual Factors Hypothetically, two individuals may commence Qsymia treatment on the same day, at the same dose, and avoid using co-administered substances.Jan 11, 2023 · In general, Phentermine chemicals do have side effects on long-term treatment. One of the most common side effects is dry mouth. Aside from this, you may also experience nervousness or jitteriness ... Jan 6, 2021 · During the last few decades, some anti-obesity drugs were used to treat morbid obesity; however, many of them were removed from the market owing to long-term side effects, particularly cardiovascular issues . Since then, anti-obesity drug development process focusses on both weight loss efficacy and cardiovascular safety. .